Pollard V W, Malim M H
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6148, USA.
Annu Rev Microbiol. 1998;52:491-532. doi: 10.1146/annurev.micro.52.1.491.
The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal. These essential peptide motifs have now been shown to function by accessing cellular signal-mediated pathways for nuclear import and nuclear export. HIV-1 Rev therefore represents an excellent system with which to study aspects of transport across the nuclear envelope.
含内含子的HIV-1 RNA的核输出严重依赖于Rev的活性，Rev是一种病毒编码的序列特异性RNA结合蛋白。Rev穿梭于细胞核和细胞质之间，同时含有核定位信号和核输出信号。现已证明，这些重要的肽基序通过利用细胞信号介导的核输入和核输出途径发挥作用。因此，HIV-1 Rev是研究核膜转运方面的一个极佳系统。
