West W O
South Med J. 1976 Oct;69(10):1331-2.
The diagnosis of multiple myeloma was made in two white men, aged 55 and 59 years. They were treated with cyclophosphamide for 98 and 44 months respectively. Patient 1 also received a nine-month course of combined therapy with melphalan, procarbazine, and prednisone. Both developed acute erythroid leukemia, 98 and 71 months after the original diagnosis of myeloma, and died of subarachnoid hemorrhage and cardiac arrest. Patient 1 developed squamous cell carcinoma of the skin with recurrence, and Patient 2 developed anaplastic carcinoma of the urinary bladder. Palliative radiation therapy was given. The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.
两名白人男性被诊断为多发性骨髓瘤，年龄分别为55岁和59岁。他们分别接受了98个月和44个月的环磷酰胺治疗。患者1还接受了为期9个月的美法仑、丙卡巴肼和泼尼松联合治疗。两人均在骨髓瘤最初诊断后的98个月和71个月发生急性红白血病，并死于蛛网膜下腔出血和心脏骤停。患者1出现皮肤鳞状细胞癌复发，患者2出现膀胱间变性癌。给予了姑息性放射治疗。这两名男性发生红白血病加癌症提示环磷酰胺治疗继发的诱变改变。
