人类白细胞中糖皮质激素受体的证据。
Evidence for glucocorticoid receptor in human leukocytes.
作者信息
Simonsson B
出版信息
Acta Physiol Scand. 1976 Oct;98(2):131-5. doi: 10.1111/j.1748-1716.1976.tb00232.x.
The glucocorticoid uptake in vitro by human periferal leukocytes was studied. The uptake showed 2 main components, one saturable and one non-saturable. The saturable component was compared with the uptake by the specific glucocorticoid receptor in rabbit granulocytes. The similarities with the rabbit receptor in structural specificity, time course of uptake at 37 degrees C, sensitivity to metabolic inhibition by PCMS and the physiological concentration for half saturation indicate that the saturable component corresponds to a specific glucocorticoid receptor. Cells from chronic lymphatic leukemia and chronic myeloic leukemia were also studied. Only the former had a saturable glucocorticoid uptake.
研究了人外周血白细胞对糖皮质激素的体外摄取。摄取显示出两个主要成分，一个是可饱和的，一个是不饱和的。将可饱和成分与兔粒细胞中特异性糖皮质激素受体的摄取进行了比较。在结构特异性、37℃时摄取的时间进程、对对氯汞苯磺酸代谢抑制的敏感性以及半饱和的生理浓度方面与兔受体的相似性表明，可饱和成分对应于一种特异性糖皮质激素受体。还研究了慢性淋巴细胞白血病和慢性粒细胞白血病的细胞。只有前者有可饱和的糖皮质激素摄取。
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