Du L, Bakish D, Lapierre Y D, Ravindran A V, Hrdina P D
Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.
Am J Med Genet. 2000 Feb 7;96(1):56-60. doi: 10.1002/(sici)1096-8628(20000207)96:1<56::aid-ajmg12>3.0.co;2-l.
There is evidence indicating that density of 5-HT2A receptors is altered in brain regions of depressed suicide victims and in platelets of suicidal subjects with major depression or schizophrenia. Recent studies have also shown an association between the allele C of 102T/C polymorphism in the 5-HT2A receptor gene and schizophrenia. The present investigation tested the hypothesis that the observed changes in 5-HT2A receptor density in platelets of patients with major depression are a trait rather than state phenomenon and are associated with the 102 C allele in 5-HT2A receptor gene in a sample of 120 patients with major depression and a group of 131 control subjects comparable with respect to age, sex, and ethnic background. The allele and genotype frequencies of 102T/C polymorphism in 5-HT2A receptor gene were compared between patients and control subjects and between suicidal and non-suicidal patient groups. The major finding of this study was a significant association between the 102 C allele in 5-HT2A receptor gene and major depression, chi(2) = 4.5, df = 1, P = 0.03, particularly in patients with suicidal ideation, chi(2) = 8.5, df = 1, P < 0.005. Furthermore, we found that patients with a 102 C/C genotype had a significantly higher mean HAMD item 3 score (indication of suicidal ideation) than T/C or T/T genotype patients. Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:56-60, 2000.
有证据表明，在抑郁自杀受害者的脑区以及患有重度抑郁症或精神分裂症的自杀者的血小板中，5-HT2A受体的密度发生了改变。最近的研究还表明，5-HT2A受体基因中102T/C多态性的C等位基因与精神分裂症之间存在关联。本研究检验了以下假设：在120名重度抑郁症患者和一组131名在年龄、性别和种族背景方面与之匹配的对照受试者中，重度抑郁症患者血小板中观察到的5-HT2A受体密度变化是一种特质而非状态现象，并且与5-HT2A受体基因中的102C等位基因相关。比较了患者与对照受试者之间以及自杀和非自杀患者组之间5-HT2A受体基因中102T/C多态性的等位基因和基因型频率。本研究的主要发现是5-HT2A受体基因中的102C等位基因与重度抑郁症之间存在显著关联，卡方值=4.5，自由度=1，P=0.03，特别是在有自杀意念的患者中，卡方值=8.5，自由度=1，P<0.005。此外，我们发现具有102C/C基因型的患者的平均汉密尔顿抑郁量表第3项评分（表明有自杀意念）显著高于T/C或T/T基因型的患者。我们的结果表明，5-HT2A受体基因中的102T/C多态性主要与重度抑郁症患者的自杀意念相关。《美国医学遗传学杂志》（神经精神遗传学）96:56 - 60，2000年。
