早期生活逆境、DNA甲基化与重度抑郁症的基础研究与临床研究的桥梁搭建
Bridging Basic and Clinical Research in Early Life Adversity, DNA Methylation, and Major Depressive Disorder.
作者信息
Brown Amanda, Fiori Laura M, Turecki Gustavo
机构信息
McGill Group for Suicide Studies, Department of Psychiatry, McGill University, Montreal, QC, Canada.
出版信息
Front Genet. 2019 Mar 22;10:229. doi: 10.3389/fgene.2019.00229. eCollection 2019.
Abstract
Early life adversity (ELA)- including childhood physical, emotional, and sexual abuse, as well as childhood neglect- is an important predictive factor for negative psychopathology, including Major Depressive Disorder (MDD). ELA can epigenetically regulate key emotional and behavioral systems in ways that can stably persist into adulthood and contribute to the development of MDD and other psychopathology. DNA methylation has been one of the most investigated forms of epigenetic regulation in ELA to MDD pathway. From these studies, genes and sites associated with ELA/MDD have been identified and should be further investigated in order to identify potential avenues for intervention.
摘要
早期生活逆境（ELA）——包括童年期的身体虐待、情感虐待和性虐待，以及童年期被忽视——是包括重度抑郁症（MDD）在内的负面精神病理学的一个重要预测因素。ELA可以通过表观遗传方式调节关键的情绪和行为系统，这些方式能够稳定地持续到成年期，并促成MDD和其他精神病理学的发展。DNA甲基化一直是ELA至MDD通路中研究最多的表观遗传调控形式之一。从这些研究中，已鉴定出与ELA/MDD相关的基因和位点，为了确定潜在的干预途径，应对其进行进一步研究。
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