Buysschaert M, Hermans M P
Service d'Endocrinologie et Nutrition, Cliniques Universitaires St Luc, Bruxelles, Belgique.
Acta Clin Belg. 1999 Dec;54(6):328-33. doi: 10.1080/17843286.1999.11754256.
The aim of the study was to evaluate the current antihyperglycaemic and antihypertensive treatment schemes as well as the quality of metabolic control and blood pressure in a population with type 2 diabetes, in view of the United Kingdom Prospective Diabetes Study (UKPDS) data. 318 patients were included. 44% were treated with metformin and/or sulfonylurea. 44% received insulin in monotherapy or combined with oral drugs. HbA1c was 8.0 (7.9-9.4)% (median; percentiles 25-75). Chronic neurological and vascular (micro- and macroangiopathy) complications were present in 21-43% of patients and were related to glycaemic control. (Un)treated hypertension was found in 59% of patients. Main treatments were ACE-inhibitors (40%), calcium channel antagonists and diuretics (20%) and/or beta-blockers (18%). Systolic and diastolic blood pressure were 147 +/- 22 and 86 +/- 12 mm/Hg (mean +/- 1 SD). In conclusion, overall glycaemic control of a type 2 diabetic population remains slightly unsatisfactory in view of the UKPDS recommendations. In contrast, blood pressure control was adequate.
鉴于英国前瞻性糖尿病研究(UKPDS)的数据,本研究旨在评估2型糖尿病患者当前的降糖和降压治疗方案以及代谢控制和血压控制质量。共纳入318例患者。44%的患者接受二甲双胍和/或磺脲类药物治疗。44%的患者接受胰岛素单药治疗或与口服药物联合治疗。糖化血红蛋白(HbA1c)为8.0(7.9 - 9.4)%(中位数;第25 - 75百分位数)。21% - 43%的患者存在慢性神经和血管(微血管和大血管病变)并发症,且与血糖控制有关。59%的患者发现有(未)治疗的高血压。主要治疗药物为血管紧张素转换酶抑制剂(ACEI)(40%)、钙通道拮抗剂和利尿剂(20%)和/或β受体阻滞剂(18%)。收缩压和舒张压分别为147±22和86±12 mmHg(平均值±1标准差)。总之,根据UKPDS的建议,2型糖尿病患者的总体血糖控制仍稍显不理想。相比之下,血压控制较为充分。