Marković D M, Davidović L B, Lotina S I, Kostić D M, Cinara I S, Svetković S D, Marković M, Zivanović N
Institute of Cardiovascular Diseases, Clinical Centre of Serbia, Belgrade.
Srp Arh Celok Lek. 1999 Nov-Dec;127(11-12):365-70.
The small choice of graft materials is one of the greatest problems in femoro-popliteal (F-P) bypass reconstructions. Besides all biosynthetics(2-5) and synthetics(6) graft materials, there is no right alternative for autologous saphenous vein graft in F-P reconstructions. There are two main techniques for F-P reconstructions: "reversed" and "in situ". The aim of this study is the comparison of the long-term patency between "reversed" and "in situ" F-P bypasses.
In the study were included 191 patients with "reversed" and 99 patients with "in situ" F-P bypass grafts operated on between 1988 and 1994. There were 153 (80.10%) male and 38 (19.90%) female patients in the group with "reversed" bypass, and 78 (78.78%) male and 21 (21.22%) female patients in the group with "in situ" bypass. The average age of all patients was 59.04 (27-80) years. Eighty five (44.5%) patients in the group with "reversed" F-P bypass had diabetes mellitus and 43 (43.43%) in the group with "in situ" bypass. One hundred and fifty two (79.68%) patients in the group with "reversed" bypass were cigarette smokers and as 80 (80.8%) in the group with "in situ" bypass. In Table 1 the Fontain classification of occlusive diseases in operated patients is presented. The early proximal reconstructions were performed in 49 patients with "reversed" and 16 patients with "in situ" bypasses (Table 2). The associated proximal reconstructions were performed in 21 patients with "reversed" and in 14 patients with "in situ" bypasses (Table 3). All patients were controlled by physical and Doppler ultrasonographic examination immediately after the operation, after 1, 3, 6 months, and then every year postoperativelly. In cases with suspected graft occlusion or any other complication, control angiographic examinations was also performed. The statistical analysis of the results was done using "Life table" analysis.
The patients were followed-up from 3 to 10 years. The results of "life-table" analysis are presented in Tables 4-8 and Graph 1. The "in situ" technique showed statistically significant better long-term patency compared to "reversed" technique, after 2 and 10 years (p < 0.05). The immediate patency in cases with "reversed" bypass was 98.96%, while limb salvage was 97.91%. In the same group long-term patency was 72.8% and limb salvage 73.9%. In the group with "in situ" bypasses the immediate patency as well as limb salvage were 96.97%. In the same group long-term patency was 73.8% and limb salvage 77.2%. In Table 5 potential advantages of the "in situ" F-P bypass technique are shown (16-21). However, there are controversial data on clinical results of both bypasses. Some authors described better long-term results of the "in situ" F-P bypass technique (28-30), while according to other data there are no significant differences between these two bypass groups (31-33). Most authors emphasized the two advantages of "in situ" bypasses in F-P reconstructions: a small diameter of the saphenous vein; in cases with pure run off (34-36).
移植物材料选择有限是股腘(F-P)旁路重建中最大的问题之一。除了所有生物合成材料(2-5)和合成材料(6)移植物外,在F-P重建中,自体隐静脉移植物没有合适的替代物。F-P重建有两种主要技术:“逆行”和“原位”。本研究的目的是比较“逆行”和“原位”F-P旁路的长期通畅率。
本研究纳入了1988年至1994年间接受“逆行”F-P旁路手术的191例患者和接受“原位”F-P旁路手术的99例患者。“逆行”旁路组有153例(80.10%)男性和38例(19.90%)女性患者,“原位”旁路组有78例(78.78%)男性和21例(21.22%)女性患者。所有患者的平均年龄为59.04(27-80)岁。“逆行”F-P旁路组中有85例(44.5%)患者患有糖尿病,“原位”旁路组中有43例(43.43%)。“逆行”旁路组中有152例(79.68%)患者吸烟,“原位”旁路组中有80例(80.8%)。表1列出了手术患者闭塞性疾病的Fontain分类。49例接受“逆行”旁路手术的患者和16例接受“原位”旁路手术的患者进行了早期近端重建(表2)。21例接受“逆行”旁路手术的患者和14例接受“原位”旁路手术的患者进行了相关近端重建(表3)。所有患者在术后立即、术后1、3、6个月以及之后每年接受体格检查和多普勒超声检查。在怀疑移植物闭塞或任何其他并发症的情况下,还进行了对照血管造影检查。结果的统计分析采用“生命表”分析。
患者随访3至10年。“生命表”分析结果见表4-8和图1。与“逆行”技术相比,“原位”技术在2年和10年后显示出统计学上显著更好的长期通畅率(p < 0.05)。“逆行”旁路患者的即时通畅率为98.96%,肢体挽救率为97.91%。在同一组中,长期通畅率为72.8%,肢体挽救率为73.9%。在“原位”旁路组中,即时通畅率和肢体挽救率均为96.97%。在同一组中,长期通畅率为73.8%,肢体挽救率为77.2%。表5显示了“原位”F-P旁路技术的潜在优势(16-21)。然而,关于两种旁路手术临床结果的数据存在争议。一些作者描述了“原位”F-P旁路技术更好的长期结果(28-30),而根据其他数据,这两个旁路组之间没有显著差异(31-33)。大多数作者强调了“原位”旁路在F-P重建中的两个优势:隐静脉直径小;在单纯流出道的情况下(34-36)。