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睫状体恶性黑色素瘤的质子照射

Proton irradiation of malignant melanoma of the ciliary body.

作者信息

Gragoudas E S, Goitein M, Koehler A, Wagner M S, Verhey L, Tepper J, Suit H D, Schneider R J, Johnson K N

出版信息

Br J Ophthalmol. 1979 Feb;63(2):135-9. doi: 10.1136/bjo.63.2.135.

DOI:10.1136/bjo.63.2.135
PMID:106873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1043415/
Abstract

This is our first case of malignant melanoma of the ciliary body treated with proton beam irradiation, a technique that we developed for irradiating choroidal melanomas. After 21 months of follow-up no growth of the tumour has been observed, and shrinkage of the tumour was noted on the follow-up photographs and by ultrasonography. The 32P uptake test, which was positive before treatment, turned negative 14 months after irradiation. The described technique of proton beam irradiation might offer an alternative for the treatment of ciliary body melanomas when the present techniques of iridocyclectomy cannot be applied because of the size of the lesion.

摘要

这是我们首例用质子束照射治疗的睫状体恶性黑色素瘤，质子束照射技术是我们研发用于照射脉络膜黑色素瘤的。经过21个月的随访，未观察到肿瘤生长，随访照片和超声检查均显示肿瘤有缩小。治疗前呈阳性的32P摄取试验在照射后14个月转为阴性。当因病变大小而无法应用目前的虹膜睫状体切除术时，所述的质子束照射技术可能为睫状体黑色素瘤的治疗提供一种替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/a432c06f4880/brjopthal00206-0069-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/6b97b9fde520/brjopthal00206-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/0b935e22d182/brjopthal00206-0069-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/92b52f6bd3ae/brjopthal00206-0069-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/eb83e6ac8b0c/brjopthal00206-0069-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/70ed52f76fa2/brjopthal00206-0069-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/a432c06f4880/brjopthal00206-0069-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/6b97b9fde520/brjopthal00206-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/0b935e22d182/brjopthal00206-0069-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/92b52f6bd3ae/brjopthal00206-0069-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/eb83e6ac8b0c/brjopthal00206-0069-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/70ed52f76fa2/brjopthal00206-0069-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/1043415/a432c06f4880/brjopthal00206-0069-f.jpg

相似文献

1
Proton irradiation of malignant melanoma of the ciliary body.睫状体恶性黑色素瘤的质子照射
Br J Ophthalmol. 1979 Feb;63(2):135-9. doi: 10.1136/bjo.63.2.135.
2
Proton beam irradiation. An alternative to enucleation for intraocular melanomas.质子束照射：眼内黑色素瘤眼球摘除术的替代方法。
Ophthalmology. 1980 Jun;87(6):571-81. doi: 10.1016/s0161-6420(80)35212-3.
3
[Homolateral episcleral metastasis or surgical seeding of a proton-irradiated ciliary body melanoma?].[质子照射睫状体黑色素瘤的同侧巩膜外转移或手术种植？]
Klin Monbl Augenheilkd. 1988 May;192(5):579-81. doi: 10.1055/s-2008-1050182.
4
Long-term risk of local failure after proton therapy for choroidal/ciliary body melanoma.质子治疗脉络膜/睫状体黑色素瘤后局部复发的长期风险。
Trans Am Ophthalmol Soc. 2002;100:43-8; discussion 48-9.
5
[Experience in the treatment of eye tumors using a narrow medical proton beam].
Med Radiol (Mosk). 1987 Aug;32(8):61-6.
6
[Technical aspects of proton irradiation of intraocular tumors].[眼内肿瘤质子照射的技术方面]
Med Radiol (Mosk). 1991;36(9):49-52.
7
Proton irradiation of small choroidal malignant melanomas.小脉络膜恶性黑色素瘤的质子照射
Am J Ophthalmol. 1977 May;83(5):665-73. doi: 10.1016/0002-9394(77)90133-7.
8
ITEP synchrotron proton beam in radiotherapy.放疗中的ITEP同步加速器质子束。
Int J Radiat Oncol Biol Phys. 1984 Feb;10(2):185-95. doi: 10.1016/0360-3016(84)90003-8.
9
[Ring recurrence of ciliary body melanoma after proton-beam therapy].[质子束治疗后睫状体黑色素瘤的环状复发]
J Fr Ophtalmol. 1997;20(9):697-700.
10
Proton beam therapy for the treatment of uveal melanoma in Scotland.质子束疗法在苏格兰治疗葡萄膜黑色素瘤。
Br J Ophthalmol. 2011 Dec;95(12):1691-5. doi: 10.1136/bjo.2010.195594. Epub 2011 Jan 7.

引用本文的文献

1
A review of image-guided radiotherapy.图像引导放射治疗综述。
Radiol Phys Technol. 2009 Jan;2(1):1-12. doi: 10.1007/s12194-008-0045-y. Epub 2008 Dec 16.

本文引用的文献

1
PARTIAL CYCLECTOMY. SOME FURTHER MODIFICATIONS IN TECHIQUE.部分睫状体切除术。技术上的一些进一步改进。
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Dosimetry of proton beams using small silicon diodes.使用小型硅二极管进行质子束剂量测定
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Surgery of tumours of the ciliary body and base of the iris.睫状体和虹膜根部肿瘤的手术
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Malignant melanoblastoma of the choroid.脉络膜恶性黑素细胞瘤
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Iridocyclectomy. A review. Gleanings from the literature.虹膜睫状体切除术。综述。文献综述
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Excision of tumours in the iris and the ciliary body.
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Surgery for tumors of the iris and ciliary body.
Am J Ophthalmol. 1968 Aug;66(2):173-84. doi: 10.1016/0002-9394(68)92062-x.
9
Proton irradiation of simulated ocular tumors.模拟眼部肿瘤的质子辐照。
Invest Ophthalmol. 1975 Jul;14(7):547-555.
10
Proton irradiation of small choroidal malignant melanomas.小脉络膜恶性黑色素瘤的质子照射
Am J Ophthalmol. 1977 May;83(5):665-73. doi: 10.1016/0002-9394(77)90133-7.