Constable I J, Koehler A M, Schmidt R A
Invest Ophthalmol. 1975 Jul;14(7):547-555.
Silicone sponges were sutured to the sclera of owl monkeys to create an indentation which would simulate a tumor of the posterior segment of the eye. A tantalum clip inserted in the silicone sponge served as a marker for radiographic localization of the simulated tumors. The acute lesions obtained on the retina and choroid after moderately high doses of proton irradiation suggest that this method of aiming the proton beam will be adquate for human clinical trials.
将硅胶海绵缝合到夜猴的巩膜上，制造一个压痕，模拟眼后段肿瘤。插入硅胶海绵中的钽夹用作模拟肿瘤放射成像定位的标记物。中等高剂量质子辐照后在视网膜和脉络膜上产生的急性病变表明，这种质子束瞄准方法适用于人体临床试验。
