Coppolino M G, Dedhar S
Division of Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Int J Biochem Cell Biol. 2000 Feb;32(2):171-88. doi: 10.1016/s1357-2725(99)00043-6.
The integrin family of cell surface glycoproteins functions primarily as receptors for extracellular matrix ligands. There are now many well characterized integrin-ligand interactions which are known to influence many aspects of cell behaviour including cell morphology, cell adhesion, cell migration as well as cellular proliferation and differentiation. However, in fulfilling these functions, integrins are not simple adhesion receptors that physically mediate connections across the plasma membrane. Rather, integrin function itself is highly regulated, largely through the formation of specific associations with both structural and regulatory components within cells. It is these intracellular interactions which allow integrin function to effect many biochemical signalling pathways and therefore to impinge upon complex cellular activities. Recently, much research has focused on elucidating the molecular mechanisms which control integrin function and the molecular processes which transduce integrin-mediated signalling events. In this review, we discuss progress in the field of integrin signal transduction including, where applicable, potential therapeutic applications arising from the research.
细胞表面糖蛋白的整合素家族主要作为细胞外基质配体的受体发挥作用。现在有许多特征明确的整合素-配体相互作用，已知这些相互作用会影响细胞行为的许多方面，包括细胞形态、细胞黏附、细胞迁移以及细胞增殖和分化。然而，在履行这些功能时，整合素并非简单的物理介导跨质膜连接的黏附受体。相反，整合素功能本身受到高度调控，主要是通过与细胞内的结构和调节成分形成特定关联来实现。正是这些细胞内相互作用使得整合素功能能够影响许多生化信号通路，从而影响复杂的细胞活动。最近，许多研究集中在阐明控制整合素功能的分子机制以及转导整合素介导的信号事件的分子过程。在这篇综述中，我们讨论整合素信号转导领域的进展，包括在适用情况下该研究产生的潜在治疗应用。
