Longhurst C M, Jennings L K
University of Tennessee, Memphis, Department of Medicine 38163, USA.
Cell Mol Life Sci. 1998 Jun;54(6):514-26. doi: 10.1007/s000180050180.
Integrins, expressed on virtually every cell type, are proteins that mediated cellular interactions with components of the extracellular matrix (ECM) and cell surface integral plasma membrane proteins. In addition, integrins interact with the cytoskeleton and through this process participate in cell migration, tissue organization, cell growth, haemostasis, inflammation, target recognition of lymphocytes and the differentiation of many cell types. Signals generated from ligand-integrin interactions are propagated via the integrin cytoplasmic tails to signal transduction pathways within the cell (outside-in signalling). Information from within the cell can also be transmitted to the outside via integrin affinity modulation (inside-out signalling). Protein tyrosine phosphorylation has a central role in integrin-initiated cell signalling, leading to cytoskeletal organization and focal adhesion formation. This review will examine the current understanding of integrin function, focusing on the intracellular consequences of integrin-ligand interaction.
整合素几乎在每种细胞类型上都有表达，是介导细胞与细胞外基质（ECM）成分相互作用的蛋白质以及细胞表面整合质膜蛋白。此外，整合素与细胞骨架相互作用，并通过这一过程参与细胞迁移、组织构建、细胞生长、止血、炎症、淋巴细胞的靶标识别以及多种细胞类型的分化。配体 - 整合素相互作用产生的信号通过整合素细胞质尾部传递到细胞内的信号转导途径（外向信号传导）。细胞内的信息也可以通过整合素亲和力调节传递到细胞外（内向信号传导）。蛋白质酪氨酸磷酸化在整合素启动的细胞信号传导中起核心作用，导致细胞骨架组织和粘着斑形成。本综述将探讨目前对整合素功能的理解，重点关注整合素 - 配体相互作用的细胞内后果。
