Kao T C, Cruess D F, Garner D, Foley J, Seay T, Friedrichs P, Thrasher J B, Mooneyhan R D, McLeod D G, Moul J W
Department of Preventive Medicine and Biometrics, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20852, USA.
J Urol. 2000 Mar;163(3):858-64.
We determined the incidence of patient self-reported post-prostatectomy incontinence, impotence, bladder neck contracture and/or urethral stricture, sexual function satisfaction, quality of life and willingness to undergo treatment again in a large multicenter group of men who underwent radical prostatectomy. We also determined whether the morbidities of sexual function satisfaction, quality of life and bladder neck contracture and/or urethral stricture are predictable from demographic and postoperative prostate cancer factors.
A self-reporting questionnaire was completed and returned by 1,069 of 1,396 eligible patients (77%) who underwent radical prostatectomy between 1962 and 1997. Of the respondents 868 (85.7%) underwent surgery after 1990 and in all prostatectomy had been done a minimum of 6 months previously. Questionnaire results were independently analyzed by a third party for morbidity tabulation and the association of patient reported satisfaction.
The patient self-reported incidence of any degree of post-prostatectomy incontinence, impotence and bladder neck contracture or urethral stricture was 65.6%, 88.4% and 20.5%, respectively. The incidence of incontinence requiring protection was 33% and only 2.8% of respondents had persistent bladder neck contracture or urethral stricture. Although incontinence and impotence significantly affected self-reported sexual function satisfaction, quality of life and willingness to undergo treatment again (p = 0.001), 77.5% of patients would elect surgery again. This finding remained true even after adjusting for demographic variables, and the time between surgery and the survey by multiple logistic regression.
Although radical prostatectomy morbidity is common and affects self-reported overall quality of life, most patients would elect the same treatment again. Impotence and post-prostatectomy incontinence were significantly associated with sexual function satisfaction, quality of life and willingness to undergo treatment again. Bladder neck contracture and/or urethral stricture was associated with willingness to undergo treatment again after adjusting for demographic variables and time from surgery to the survey.
我们确定了在接受根治性前列腺切除术的一大组多中心男性患者中,患者自我报告的前列腺切除术后尿失禁、阳痿、膀胱颈挛缩和/或尿道狭窄的发生率、性功能满意度、生活质量以及再次接受治疗的意愿。我们还确定了性功能满意度、生活质量以及膀胱颈挛缩和/或尿道狭窄的发病率是否可从人口统计学和术后前列腺癌因素中预测。
1962年至1997年间接受根治性前列腺切除术的1396名 eligible 患者中有1069名(77%)完成并返回了一份自我报告问卷。在受访者中,868名(85.7%)在1990年后接受了手术,且所有前列腺切除术均在至少6个月前完成。问卷结果由第三方独立分析,用于发病率列表和患者报告满意度的关联分析。
患者自我报告的任何程度的前列腺切除术后尿失禁、阳痿以及膀胱颈挛缩或尿道狭窄的发生率分别为65.6%、88.4%和20.5%。需要防护的尿失禁发生率为33%,仅有2.8%的受访者存在持续性膀胱颈挛缩或尿道狭窄。尽管尿失禁和阳痿显著影响自我报告的性功能满意度、生活质量以及再次接受治疗的意愿(p = 0.001),但77.5%的患者仍会再次选择手术。即使在通过多元逻辑回归调整人口统计学变量以及手术与调查之间的时间后,这一发现仍然成立。
尽管根治性前列腺切除术的发病率很常见且会影响自我报告的总体生活质量,但大多数患者仍会再次选择相同的治疗方法。阳痿和前列腺切除术后尿失禁与性功能满意度、生活质量以及再次接受治疗的意愿显著相关。在调整人口统计学变量和从手术到调查的时间后,膀胱颈挛缩和/或尿道狭窄与再次接受治疗的意愿相关。