为什么是干细胞？

Why stem cells?

作者信息

van der Kooy D, Weiss S

机构信息

Department of Anatomy and Cell Biology, University of Toronto Faculty of Medicine, Toronto, Ontario, M5S 1A8 Canada.

出版信息

Science. 2000 Feb 25;287(5457):1439-41. doi: 10.1126/science.287.5457.1439.

DOI:10.1126/science.287.5457.1439

PMID:10688784

Abstract

Stem cells are viewed from the perspectives of their function, evolution, development, and cause. Counterintuitively, most stem cells may arise late in development, to act principally in tissue renewal, thus ensuring an organism's long-term survival. Surprisingly, recent reports suggest that tissue-specific adult stem cells have the potential to contribute to replenishment of multiple adult tissues.

摘要

干细胞是从其功能、进化、发育和成因等角度来观察的。与直觉相反的是，大多数干细胞可能在发育后期出现，主要作用于组织更新，从而确保生物体的长期存活。令人惊讶的是，最近的报告表明，组织特异性成体干细胞有可能促进多种成体组织的补充。