Tough D F, Sun S, Zhang X, Sprent J
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, UK.
Vaccine. 2000 Feb 25;18(16):1642-8. doi: 10.1016/s0264-410x(99)00500-9.
Mature T cells can be classified on the basis of cell surface markers into naïve- and memory-phenotype cells. These phenotypically-defined subsets exhibit distinct kinetic behaviour in vivo. Thus, naïve-phenotype T cells persist long-term in a non-dividing state, while memory-phenotype T cells include cycling cells and have a more rapid rate of turnover. We have investigated the possibility that the different kinetic behaviour of naïve- and memory-phenotype T cells reflects a differential responsiveness to cytokines. It was discovered that memory-, but not naïve-, phenotype T cells were stimulated to proliferate by a variety of infection-induced cytokines. These results suggest that cytokines contribute to the high background rate of turnover exhibited by memory T cells.
成熟T细胞可根据细胞表面标志物分为初始型和记忆型细胞。这些表型定义的亚群在体内表现出不同的动力学行为。因此，初始型T细胞长期处于非分裂状态，而记忆型T细胞包括循环细胞且更新速率更快。我们研究了初始型和记忆型T细胞不同的动力学行为是否反映了对细胞因子的不同反应性。结果发现，多种感染诱导的细胞因子可刺激记忆型而非初始型T细胞增殖。这些结果表明，细胞因子促成了记忆T细胞呈现的高背景更新率。
