Koseki K, Nakano M, Takaiwa M, Kamata T, Yosida J
Department of Urology, Yonezawa City Hospital.
Nihon Hinyokika Gakkai Zasshi. 2000 Jan;91(1):29-32. doi: 10.5980/jpnjurol1989.91.29.
We report 3 cases of suicide attempts in postoperative patients with renal cancer after alpha interferon withdrawal. In the first patient, depression occurred during interferon therapy, and remained after interferon withdrawal. A suicide attempt occurred 7 months after interferon withdrawal. In the second and third patients, depression did not occur during interferon therapy, but suicide attempts occurred 40 days and 7 months after interferon withdrawal, respectively. Depression does not always disappear after interferon is discontinued. Psychiatric supervision should be continued even more frequently after interferon withdrawal. The increased risk of psychiatric side effects due to interferon, as well as their severity, suggest that interferon should be administered with caution.
我们报告了3例肾癌术后患者在停用α干扰素后自杀未遂的病例。第一例患者在干扰素治疗期间出现抑郁，停用干扰素后仍持续存在。停用干扰素7个月后发生自杀未遂。第二例和第三例患者在干扰素治疗期间未出现抑郁，但分别在停用干扰素40天和7个月后发生自杀未遂。停用干扰素后抑郁并非总会消失。即使在停用干扰素后，也应更频繁地继续进行精神科监护。干扰素导致精神科副作用的风险增加及其严重程度表明，应谨慎使用干扰素。
