Dalgleish S
Calgary Regional Health Authority.
Off J Can Assoc Crit Care Nurs. 1999 Summer;10(2):18-22.
Health care professionals who care for neonates have few treatment options for the management of mild, sporadic painful events, such as those associated with venipuncture. A number of research studies have demonstrated sucrose to be an efficacious analgesic for mild procedural pain in neonates. The historical therapy of the "sugar nipple" has even been replaced with sucrose. A discussion of the pharmacologic principles, available research regarding dose-response relationships and implications for nursing care is presented in this article to allow the reader to consider how this adjunctive therapy may be incorporated into care of the neonate. Rather than considering sucrose as a replacement for traditional analgesics, this easily administered and seemingly safe intervention could be used as another adjunctive therapy in treating mild pain for neonates. Future directions of research may identify the precise mechanism of action that sucrose takes in the neonate, the gestational and chronological ages when sucrose is most efficacious, and the consequences of frequent or repeated dosing with term and low birth weight infants.
照顾新生儿的医护人员在处理轻度、偶发性疼痛事件（如与静脉穿刺相关的疼痛）时，治疗选择有限。多项研究表明，蔗糖对新生儿轻度操作疼痛是一种有效的镇痛药。甚至“糖乳头”这种传统疗法也已被蔗糖所取代。本文讨论了药理学原理、关于剂量反应关系的现有研究以及对护理的影响，以使读者能够考虑如何将这种辅助疗法纳入新生儿护理中。与其将蔗糖视为传统镇痛药的替代品，这种易于给药且看似安全的干预措施可作为治疗新生儿轻度疼痛的另一种辅助疗法。未来的研究方向可能会确定蔗糖在新生儿体内的确切作用机制、蔗糖最有效的孕周和月龄，以及足月儿和低出生体重儿频繁或重复给药的后果。
