Wang J J, Ho S T, Liu Y H, Lee S C, Liu Y C, Liao Y C, Ho C M
Department of Anaesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Br J Anaesth. 1999 Nov;83(5):772-5. doi: 10.1093/bja/83.5.772.
We have evaluated the antiemetic effect of i.v. dexamethasone compared with saline in the prevention of nausea and vomiting after laparoscopic cholecystectomy. We studied 90 patients requiring general anaesthesia for laparoscopic cholecystectomy, in a randomized, double-blind, placebo-controlled study. The dexamethasone group (n = 45) received dexamethasone 8 mg i.v. and the saline group received saline 2 ml i.v. at induction of anaesthesia. Anaesthesia was maintained with isoflurane in oxygen. We found that 10% of patients in the dexamethasone group compared with 34% in the saline group reported vomiting (P < 0.05). Of note, the total incidence of nausea and vomiting was 23% in the dexamethasone group and 63% in the saline group (P < 0.001). We conclude that dexamethasone 8 mg significantly decreased the incidence of nausea and vomiting after laparoscopic cholecystectomy.
我们评估了静脉注射地塞米松与生理盐水相比，在预防腹腔镜胆囊切除术后恶心和呕吐方面的止吐效果。在一项随机、双盲、安慰剂对照研究中，我们研究了90例需要全身麻醉进行腹腔镜胆囊切除术的患者。地塞米松组（n = 45）在麻醉诱导时静脉注射8 mg地塞米松，生理盐水组静脉注射2 ml生理盐水。麻醉用异氟醚和氧气维持。我们发现，地塞米松组10%的患者报告有呕吐，而生理盐水组为34%（P < 0.05）。值得注意的是，地塞米松组恶心和呕吐的总发生率为23%，生理盐水组为63%（P < 0.001）。我们得出结论，8 mg地塞米松显著降低了腹腔镜胆囊切除术后恶心和呕吐的发生率。
