Rockwell K, Bockheim-McGee C, Jones E, Kwon I W
Investigational Drug Service, University of Pennsylvania Medical Center, Philadelphia, USA.
Am J Health Syst Pharm. 1999 Feb 15;56(4):337-44. doi: 10.1093/ajhp/56.4.337.
The results of a survey on the status of pharmacy-based investigational drug services and ways in which some institutions have adapted to recent changes that may affect research are presented. A 99-item survey on investigational drug services was sent in February 1997 to pharmacy directors at 1495 hospitals affiliated with teaching institutions throughout the United States. The survey covered workload, inpatient and outpatient pharmaceutical services, marketing of services, quality assurance, committee involvement, funding sources, computerization, and educational activities. The response rate was 21%; 68% of the respondents were from sites involved in dispensing drugs used for clinical research, with pharmacies at larger hospitals being more likely to dispense investigational drugs than pharmacies at smaller hospitals. The pharmacies participated in a mean 51 active protocols for every full-time-equivalent employee budgeted to research protocols. The correlation between staffing level and number of protocols was high. The service provided most often was the maintenance of drug accountability records for study drugs dispensed to inpatients and outpatients. There was wide variation in the types of services provided to researchers by the pharmacies. Basic services, such as dispensing and inventory control, were provided by nearly all the pharmacies, whereas more-specialized services tended to be provided more often at institutions more heavily committed to research. Pharmacy-based investigational drug services at hospitals affiliated with teaching institutions offered basic services, such as dispensing and inventory control, almost universally and offered specialized services to varying degrees.
本文介绍了一项关于药学基础研究用药物服务现状的调查结果，以及一些机构为适应可能影响研究的近期变化所采取的方式。1997年2月，一项针对1495家美国教学机构附属医院药房主任的、包含99个项目的研究用药物服务调查被发出。该调查涵盖了工作量、住院和门诊药学服务、服务营销、质量保证、委员会参与情况、资金来源、计算机化以及教育活动等方面。回复率为21%；68%的受访者来自参与临床研究用药调配的机构，大型医院的药房比小型医院的药房更有可能调配研究用药物。每家为研究方案配备全职等效员工的药房平均参与51项现行方案。人员配备水平与方案数量之间的相关性很高。最常提供的服务是维护分发给住院和门诊患者的研究用药物的药物责任记录。各药房向研究人员提供的服务类型差异很大。几乎所有药房都提供诸如调配和库存控制等基本服务，而更专业化的服务往往在更热衷于研究的机构中更常提供。教学机构附属医院基于药学的研究用药物服务几乎普遍提供诸如调配和库存控制等基本服务，并在不同程度上提供专业化服务。
