Brackenbury T D
Biological Control Products (SA) (Pty) Ltd, South Africa.
Ann Trop Med Parasitol. 1999 Jul;93(5):519-26. doi: 10.1080/00034989958267.
A lethal concentration of a crude, aqueous extract of Agave attenuata was applied as a contact poison to Bulinus africanus, the intermediate host of Schistosoma haematobium, for a 24-h period. The gross histopathological effects of the extract on the epithelium of the digestive tract were then studied. A graded series of cellular injuries to the epithelial layer was observed along the length of the tract. These included the loss of cilia and brush border, disruption of the epithelial layer, cellular vacuolation, swelling and rupture, and the discharge of secretory products from mucous gland cells. The results of the microscopy show that epithelial tissue is probably a primary target of the molluscicide. The cytological injuries induced by extracts of A. attenuata indicate that the molluscicide acts by disrupting the osmoregulatory mechanisms of the epithelial cells, but further, detailed studies are required to confirm this.
将龙舌兰粗水提取物的致死浓度作为接触性毒药，作用于埃及血吸虫中间宿主非洲小泡螺24小时。随后研究了该提取物对消化道上皮的大体组织病理学影响。沿消化道全长观察到上皮层出现一系列分级的细胞损伤。这些损伤包括纤毛和刷状缘丧失、上皮层破坏、细胞空泡化、肿胀和破裂，以及黏液腺细胞分泌产物的排出。显微镜检查结果表明，上皮组织可能是杀螺剂的主要作用靶点。龙舌兰提取物引起的细胞学损伤表明，杀螺剂通过破坏上皮细胞的渗透调节机制发挥作用，但需要进一步详细研究来证实这一点。
