[对具有耐药性的1型单纯疱疹病毒毒株繁殖的抑制作用]
[Inhibition of the reproduction of strains of the herpes simplex virus type 1 with drug resistance].
作者信息
Andronova V L, Galegov G A
机构信息
D. I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow.
出版信息
Antibiot Khimioter. 2000;45(1):5-9.
Inhibition of type-1 herpes simplex strains resistant to acyclovir, phosphonoacetic acid and their combination by combined use of three drugs with different mechanisms of action capable of suppressing reproduction of the acyclovir resistant strain was studied. The combinations used were the following: Ara-A + ribavirin + phosphonoformic acid, Xylo-A + ribavirin + phosphonoformic acid and Ph-ACH + Ara-A + ribavirin. The former two combinations had a synergistic action on the standard strain L2 whose drug susceptibility had not undergone changes as well as on the acyclovir resistant strain. As for the strain resistant to phosphonoacetic acid and to acyclovir + phosphonoacetic acid the effect was additive. Ph-ACH + Ara-A + ribavirin had a marked synergistic action on all the strains tested.
研究了联合使用三种具有不同作用机制、能够抑制阿昔洛韦耐药株繁殖的药物对1型单纯疱疹病毒株（对阿昔洛韦、膦甲酸钠及其组合耐药）的抑制作用。所使用的组合如下：阿糖腺苷+利巴韦林+膦甲酸、木糖阿糖腺苷+利巴韦林+膦甲酸以及苯乙酰阿糖胞苷+阿糖腺苷+利巴韦林。前两种组合对药物敏感性未发生变化的标准株L2以及阿昔洛韦耐药株具有协同作用。对于对膦甲酸钠以及对阿昔洛韦+膦甲酸钠耐药的毒株，其作用为相加性。苯乙酰阿糖胞苷+阿糖腺苷+利巴韦林对所有测试毒株均具有显著的协同作用。
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