[L-赖氨酸-α-氧化酶对单纯疱疹病毒I型体外增殖的影响]
[Effect of L-lysine-a-oxidase on reproduction of herpes simplex type I virus in vitro].
作者信息
Smirnova I P, Diorditsa S V, Alekseev S B, Zaĭtsev I Z
机构信息
Department of Biochemistry, Russian Peoples Friendship University.
出版信息
Vopr Med Khim. 1998 Jul-Aug;44(4):384-7.
PMID:9845927
Abstract
L-lysin-a-oxidase (LO), a fungal enzyme catalysing oxidative deamination of L-lysin, was used for the inhibition of the reproduction of herpes simplex virus type 1 (HSV-1). Antiviral activity of LO was tested in vitro. The expression of viral antigens and CPE of HSV-1 was inhibited by LO at a concentration 0.7 mg/ml.
摘要
L-赖氨酸氧化酶（LO）是一种催化L-赖氨酸氧化脱氨的真菌酶，被用于抑制单纯疱疹病毒1型（HSV-1）的复制。在体外测试了LO的抗病毒活性。LO在浓度为0.7mg/ml时可抑制HSV-1的病毒抗原表达和细胞病变效应。
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