衰老和痴呆中的白质体积及脑室周围白质高信号
White matter volumes and periventricular white matter hyperintensities in aging and dementia.
作者信息
Smith C D, Snowdon D A, Wang H, Markesbery W R
机构信息
Department of Neurology, University of Kentucky Medical Center, Lexington 40536, USA.
出版信息
Neurology. 2000 Feb 22;54(4):838-42. doi: 10.1212/wnl.54.4.838.
OBJECTIVE
To determine the relationship between MRI periventricular white matter hyperintensities, cerebral white matter volumes, neuropathologic findings, and cognitive status in aged individuals.
BACKGROUND
The significance of periventricular white matter hyperintensities seen on MR images in aged individuals remains controversial. The Nun Study is a longitudinal cohort aging study in which all 678 initially enrolled participants agreed to autopsy neuropathologic examination.
METHODS
We used MRI to measure white matter volumes of the cerebral hemispheres in 52 formaldehyde-fixed brains for correlation with white matter and neocortical pathology, postmortem MRI observations, and cognitive measures.
RESULTS
Reduced white matter volume is associated with dementia, but periventricular white matter hyperintensities were not related to white matter volume, stroke, or dementia.
CONCLUSIONS
Our results do not support the hypothesis that periventricular hyperintensities seen on MR images have deleterious consequences in these aged individuals.
目的
确定老年个体中磁共振成像（MRI）脑室周围白质高信号、脑白质体积、神经病理学发现与认知状态之间的关系。
背景
老年个体MRI图像上脑室周围白质高信号的意义仍存在争议。修女研究是一项纵向队列衰老研究，最初招募的678名参与者均同意进行尸检神经病理学检查。
方法
我们使用MRI测量了52个用甲醛固定的大脑半球的白质体积，以与白质和新皮质病理学、死后MRI观察结果以及认知测量结果进行关联。
结果
白质体积减少与痴呆相关，但脑室周围白质高信号与白质体积、中风或痴呆无关。
结论
我们的结果不支持以下假设，即在这些老年个体中，MRI图像上的脑室周围高信号具有有害后果。
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