脑活检在HIV感染患者局灶性脑病变管理中的作用。意大利艾滋病与肿瘤合作研究组。
Role of brain biopsy in the management of focal brain lesions in HIV-infected patients. Gruppo Italiano Cooperativo AIDS & Tumori.
作者信息
Antinori A, Ammassari A, Luzzati R, Castagna A, Maserati R, Rizzardini G, Ridolfo A, Fasan M, Vaccher E, Landonio G, Scerrati M, Rocca A, Butti G, Nicolato A, Lazzarin A, Tirelli U
机构信息
Department of Infectious Diseases, IRCCS L. Spallanzani, Rome, Italy.
出版信息
Neurology. 2000 Feb 22;54(4):993-7. doi: 10.1212/wnl.54.4.993.
In this multicenter, retrospective study of 160 brain biopsies in the assessment of HIV-related focal brain lesions, diagnostic sensitivity was acceptable (87%), but the procedure carried considerable morbidity (7.5%) and mortality (3.1%). Moreover, it is not always possible to initiate the changes in therapy indicated by the results, and overall survival remains poor, with a median of 2 months. Criteria for brain biopsy for the diagnosis of focal brain lesions should be redefined to include selected patients for whom a less invasive approach does not yield a definitive diagnosis.
在这项针对160例脑活检进行的多中心回顾性研究中，用于评估与HIV相关的局灶性脑病变，诊断敏感性尚可（87%），但该操作具有相当高的发病率（7.5%）和死亡率（3.1%）。此外，依据结果进行治疗调整并非总能实现，总体生存率仍然很低，中位生存期为2个月。应重新定义用于诊断局灶性脑病变的脑活检标准，以纳入那些采用侵入性较小的方法无法得出明确诊断的特定患者。
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