Beard C M, Hartmann L C, Keeney G L, Crowson C S, Malkasian G D, O'Brien P C, Melton L J
Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
Ann Epidemiol. 2000 Feb;10(2):97-105. doi: 10.1016/s1047-2797(99)00039-3.
We updated an earlier study in this community from 1945-1974 in order to assess trends in the incidence of, risk factors for, and survival from endometrial cancer in 1975-1991.
Incidence rates were based on all new cases of endometrial cancer diagnosed among Olmsted County, Minnesota, women during the years 1975-1991, with the population denominator from decennial census data. Risk factors were assessed with conditional logistic regression comparing the incidence cases to age- and gender-matched controls with intact uteri seen the same year the case was diagnosed. Survival was assessed using the Kaplan-Meier method.
The incidence of endometrial cancer (age-adjusted to 1970 United States total) in 1975-1991 was 14.3 per 100,000 person-years, which is slightly increased from 1965-74. The rate was 21.7 per 100,000 person-years after adjustment for hysterectomy prevalence. As in the previous study, conjugated estrogen use for six months or more (odds ratio [OR] 2.71; 95% confidence interval [CI] 1.14-6.46) and body mass index (OR 1.06; 95% CI 1.01-1.11) increased the risk of endometrial cancer. The five-year relative survival rate (82%) was not improved over the earlier study.
A small increase in endometrial cancer incidence was linked to the same risk factors identified in an earlier study in this community. No improvement in survival was seen.
我们更新了此前一项关于该社区1945 - 1974年情况的研究，以评估1975 - 1991年间子宫内膜癌的发病率趋势、危险因素及生存率。
发病率基于1975 - 1991年间明尼苏达州奥姆斯特德县女性中诊断出的所有子宫内膜癌新病例，人口分母采用十年一次的人口普查数据。通过条件逻辑回归评估危险因素，将发病病例与在病例确诊同年所见的年龄和性别匹配的有完整子宫的对照进行比较。使用Kaplan - Meier方法评估生存率。
1975 - 1991年间子宫内膜癌的发病率（年龄调整至1970年美国总体水平）为每10万人年14.3例，较1965 - 1974年略有上升。调整子宫切除患病率后，发病率为每10万人年21.7例。与先前研究一样，使用共轭雌激素六个月或更长时间（比值比[OR] 2.71；95%置信区间[CI] 1.14 - 6.46）和体重指数（OR 1.06；95% CI 1.01 - 1.11）会增加子宫内膜癌风险。五年相对生存率（82%）较早期研究没有提高。
子宫内膜癌发病率的小幅上升与该社区早期研究中确定的相同危险因素有关。生存率未见改善。
