Kida K, Mimura G, Ito T, Murakami K, Ashkenazi I, Laron Z
Department of Paediatrics, Ehime University School of Medicine, Japan.
Diabet Med. 2000 Jan;17(1):59-63. doi: 10.1046/j.1464-5491.2000.00205.x.
To detect the incidence of childhood Type 1 diabetes mellitus (DM) (0-14 years) in Japan and to find out whether there is a seasonal pattern in the onset of disease and month of birth of children with diabetes.
Ascertained data for the period 1986-1990 could be collected in 35 out of 47 local government areas representing 69.4% of the childhood population (aged 0-14 years) of Japan.
A total of 1,260 children with Type 1 DM were identified (738 girls, 522 boys). With age there was a progressive increase in incidence from 0.7 to 2.1/10(5) in boys and from 0.6 to 3.5/10(5) in girls. With the exception of 1987, when a coxsackie B3 virus epidemic was registered, no seasonal variation in the month of onset was observed, nor was a seasonal pattern of the month of birth registered in this cohort.
Compared to European countries, the USA and Israel, the Japanese cohort of children with diabetes presents the following differences: the incidence is much lower, there is a preponderance of girls and there is (with one exception) no seasonal pattern.
检测日本1型糖尿病（DM）（0 - 14岁）儿童的发病率，并查明糖尿病患儿的发病季节模式以及出生月份情况。
在日本47个地方政府区域中的35个区域收集到了1986 - 1990年期间的确证数据，这些区域代表了日本69.4%的儿童人口（0 - 14岁）。
共识别出1260例1型糖尿病患儿（738名女孩，522名男孩）。随着年龄增长，男孩发病率从0.7/10⁵逐渐升至2.1/10⁵，女孩发病率从0.6/10⁵逐渐升至3.5/10⁵。除了1987年登记有柯萨奇B3病毒流行外，未观察到发病月份的季节性变化，该队列中也未登记到出生月份的季节性模式。
与欧洲国家、美国和以色列相比，日本糖尿病患儿队列呈现出以下差异：发病率低得多，女孩占多数，且（有一个例外情况）无季节性模式。
