Ursic-Bratina N, Battelino T, Krzisnik C, Laron-Kenet T, Ashkenazi I, Laron Z
University Children's Hospital, University of Ljubljana, Slovenia.
J Pediatr Endocrinol Metab. 2001 Jan;14(1):47-52. doi: 10.1515/jpem.2001.14.1.47.
The aim of this study was to find out whether there is seasonality of month of birth of children with diabetes in Slovenia and if so whether it differs from that of the general population. A cohort of 849 children and adolescents (0-14 years) with type 1 diabetes mellitus born between 1956 and 1998 were included in the study. Monthly and seasonal patterns of birth of the patients with diabetes were compared with the pattern of normal live births (n = 1,345,921) and the pattern of disease onset. Statistical analysis was made using Student's t-test to compare the means between the four seasons of the year, and single cosinor analysis for a period of 12 months. The children and adolescents with diabetes had a statistically significant different seasonality of month of birth compared to that of the general population, and an opposite pattern from the seasonality of month of onset of disease. The observations made are in accordance with observations made recently in other countries and support the hypothesis that a virus infection transmitted by the mother to the fetus during the annual viral epidemic induces the autoimmune process in the pancreatic beta-cells in genetically susceptible individuals who will subsequently develop clinical diabetes during childhood.
本研究的目的是查明斯洛文尼亚糖尿病患儿的出生月份是否存在季节性，若存在，其是否与普通人群不同。本研究纳入了1956年至1998年出生的849名1型糖尿病儿童和青少年（0至14岁）。将糖尿病患者的月度和季节性出生模式与正常活产模式（n = 1,345,921）以及疾病发病模式进行比较。使用学生t检验进行统计分析，以比较一年四个季节之间的均值，并对12个月的时间段进行单余弦分析。与普通人群相比，糖尿病儿童和青少年的出生月份季节性在统计学上有显著差异，且与疾病发病月份的季节性模式相反。所做的观察结果与其他国家最近的观察结果一致，并支持以下假设：在年度病毒流行期间，母亲将病毒感染传给胎儿，从而在基因易感性个体的胰腺β细胞中引发自身免疫过程，这些个体随后将在儿童期发展为临床糖尿病。
