Li Yuchuan, Qian Kun, Wu Di, Wang Xinli, Cui Hong, Yuan Geheng, Yuan Jinfang, Yang Lijun, Wei Liya, Cao Bingyan, Su Chang, Liang Xuejun, Liu Min, Li Wenjing, Qin Miao, Chen Jiajia, Meng Xi, Wang Rui, Su Shan, Chen Xiaobo, Chen Hui, Gong Chunxiu
Outpatient Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Department of Endocrinology, Capital Institute of Pediatrics, No. 2 Yaobao Road Chaoyang District, Beijing, 100020, China.
Diabetes Ther. 2023 Mar;14(3):519-529. doi: 10.1007/s13300-023-01367-8. Epub 2023 Jan 26.
China has a low incidence of type 1 diabetes mellitus (T1DM); however, based on the large population, the absolute numbers are high. Our aim was to assess the incidence of childhood T1DM in Beijing during 2011-2020, predicted incidence for 2025-2035, and to determine the incidence of diabetic ketosis or diabetic ketoacidosis (DK/DKA) in this population.
Data on patients aged less than 15 years of age with newly diagnosed T1DM between January 1, 2011 and December 31, 2020 was obtained from five tertiary hospitals in Beijing and retrospectively analyzed.
In all, 636 children aged less than 15 years were diagnosed with T1DM during 2011-2020. The incidence of T1DM was 3.11-5.46 per 100,000 per year, with an average increase of 5.10% per year. The age-specific incidence for ages 0-4 years, 5-9 years, and 10-14 years was 2.97, 4.69, and 4.68 per 100,000 per year, respectively. The highest average annual increase (7.07%) in incidence was for the youngest age group. DK or DKA was present at the time of diagnosis of T1DM in 84.6% of patients. The age-specific incidence of T1DM among children aged less than 15 years was predicted to be 7.32, 11.4, and 11.52 per 100,000 in 2035 for ages 0-4 years, 5-9 years, and 10-14 years, respectively.
The was a gentle increase in the incidence of childhood T1DM during 2011-2020 in Beijing. This increase is expected to continue for the next 15 years.
中国1型糖尿病（T1DM）的发病率较低；然而，基于庞大的人口基数，其绝对发病数较高。我们的目的是评估2011年至2020年期间北京儿童T1DM的发病率、预测2025年至2035年的发病率，并确定该人群中糖尿病酮症或糖尿病酮症酸中毒（DK/DKA）的发病率。
获取2011年1月1日至2020年12月31日期间北京五家三级医院新诊断为T1DM的15岁以下患者的数据，并进行回顾性分析。
2011年至2020年期间，共有636名15岁以下儿童被诊断为T1DM。T1DM的发病率为每年每10万人3.11至5.46例，平均每年增长5.10%。0至4岁、5至9岁和10至14岁年龄组的年龄别发病率分别为每年每10万人2.97例、4.69例和4.68例。发病率平均年增长率最高的是最年幼的年龄组（7.07%）。84.6%的患者在T1DM诊断时伴有DK或DKA。预计到2035年，15岁以下儿童中0至4岁、5至9岁和10至14岁年龄组的T1DM年龄别发病率分别为每10万人中7.32例、11.4例和11.52例。
2011年至2020年期间，北京儿童T1DM的发病率呈平缓上升趋势。预计在未来15年这种上升趋势仍将持续。
