Yamaguchi F, Ariga T, Yoshimura Y, Nakazawa H
Research and Development Division, Kikkoman Corporation, Noda 399, Noda-shi, Chiba Pref. 278-0037, Japan.
J Agric Food Chem. 2000 Feb;48(2):180-5. doi: 10.1021/jf990845y.
Garcinol, a polyisoprenylated benzophenone derivative, was purified from Garcinia indica fruit rind, and its antioxidative activity, chelating activity, free radical scavenging activity, and anti-glycation activity were studied. Garcinol exhibited moderate antioxidative activity in the micellar linoleic acid peroxidation system and also exhibited chelating activity at almost the same level as citrate. It also showed nearly 3 times greater DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging activity than DL-alpha-tocopherol by weight in aqueous ethanol solution. In a phenazine methosulfate/NADH-nitroblue tetrazolium system, garcinol exhibited superoxide anion scavenging activity and suppressed protein glycation in a bovine serum albumin/fructose system. Thus, garcinol might be beneficial as a potent antioxidant and a glycation inhibitor under specified conditions.
藤黄脂素是一种多异戊烯基化二苯甲酮衍生物，从印度藤黄果壳中提纯得到，并对其抗氧化活性、螯合活性、自由基清除活性及抗糖化活性进行了研究。藤黄脂素在胶束亚油酸过氧化体系中表现出中等抗氧化活性，且其螯合活性与柠檬酸盐几乎处于同一水平。在乙醇水溶液中，按重量计，它清除DPPH（1,1 - 二苯基 - 2 - 苦基肼）自由基的活性比DL-α-生育酚高出近3倍。在吩嗪硫酸甲酯/烟酰胺腺嘌呤二核苷酸/硝基蓝四氮唑体系中，藤黄脂素表现出超氧阴离子清除活性，并在牛血清白蛋白/果糖体系中抑制蛋白质糖化。因此，在特定条件下，藤黄脂素作为一种有效的抗氧化剂和糖化抑制剂可能有益。
