Moats W A, Anderson K L, Rushing J E, Buckley S
Food Animal Protection Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, College Station, Texas 77845, USA.
J Agric Food Chem. 2000 Feb;48(2):498-502. doi: 10.1021/jf990638y.
Cephapirin is one of six beta-lactam antibiotics approved for use in the treatment of food-producing animals in the United States. When used for treatment of mastitis by intramammary infusion, it is partially converted to a microbiologically active metabolite identified as deacetylcephapirin (DACEP). The degradation was followed in four cows with naturally acquired mastitis which were treated with cephapirin. DACEP persisted longer than the parent compound in the milk. When a calf was treated with cephapirin by intramuscular injection, the compound was almost completely converted to DACEP in tissues. The deacetyl form must be considered in the determination of residues in treated animals.
头孢匹林是美国批准用于治疗食用动物的六种β-内酰胺类抗生素之一。通过乳房内灌注用于治疗乳腺炎时，它会部分转化为一种具有微生物活性的代谢物，即去乙酰头孢匹林（DACEP）。对四头自然感染乳腺炎并用头孢匹林治疗的奶牛进行了降解跟踪。DACEP在牛奶中的持续时间比母体化合物更长。当通过肌肉注射用头孢匹林治疗小牛时，该化合物在组织中几乎完全转化为DACEP。在测定治疗动物的残留量时，必须考虑去乙酰形式。
