Vrij A A, Rijken J, Van Wersch J W, Stockbrügger R W
Department of Gastroenterology, University Hospital, Maastricht; the Netherlands.
Eur J Clin Invest. 2000 Mar;30(3):188-94. doi: 10.1046/j.1365-2362.2000.00616.x.
As platelet factors are important in the inflammatory response, we examined the course of platelet factor 4 and beta-thromboglobulin in relation to disease activity in inflammatory bowel disease and in giant cell arteritis.
In a prospective study, the platelet count, platelet factor 4 and beta-thromboglobulin were measured in 20 patients with Crohn's disease, 18 with ulcerative colitis and 19 with giant cell arteritis, during active and inactive disease, as well as in 51 controls without inflammation.
Platelet counts were significantly higher in active vs. inactive Crohn's disease, ulcerative colitis and giant cell arteritis. Levels of platelet factor 4 and beta-thromboglobulin were significantly higher in active inflammatory bowel disease and giant cell arteritis, as well as in inactive inflammatory bowel disease and giant cell arteritis, than in the non-inflammatory controls. A positive correlation was found between the Crohn's disease activity index and the platelet count, platelet factor 4 and beta-thromboglobulin. Also, a positive correlation was found between the ulcerative colitis activity index and beta-thromboglobulin. However, even after 12 months of follow-up, in Crohn's disease and ulcerative colitis the mean levels of platelet factor 4 and beta-thromboglobulin were significantly higher than the levels of the controls.
Platelet factors were correlated with inflammatory bowel disease activity. Levels of platelet factor 4 and beta-thromboglobulin, however, were markedly raised for a long time in clinically inactive inflammatory bowel disease, which might point to a pre-thrombotic state of disease.
由于血小板因子在炎症反应中起重要作用，我们研究了炎症性肠病和巨细胞动脉炎患者血小板因子4和β-血小板球蛋白水平与疾病活动度的关系。
在一项前瞻性研究中，我们检测了20例克罗恩病患者、18例溃疡性结肠炎患者和19例巨细胞动脉炎患者在疾病活动期和非活动期的血小板计数、血小板因子4和β-血小板球蛋白水平，同时检测了51例无炎症的对照者的上述指标。
与非活动期相比，克罗恩病、溃疡性结肠炎和巨细胞动脉炎活动期患者的血小板计数显著升高。活动期炎症性肠病和巨细胞动脉炎患者以及非活动期炎症性肠病和巨细胞动脉炎患者的血小板因子4和β-血小板球蛋白水平均显著高于非炎症对照组。克罗恩病活动指数与血小板计数、血小板因子4和β-血小板球蛋白之间呈正相关。溃疡性结肠炎活动指数与β-血小板球蛋白之间也呈正相关。然而，即使经过12个月的随访，克罗恩病和溃疡性结肠炎患者血小板因子4和β-血小板球蛋白的平均水平仍显著高于对照组。
血小板因子与炎症性肠病活动度相关。然而，在临床非活动期炎症性肠病中，血小板因子4和β-血小板球蛋白水平长期显著升高，这可能提示疾病存在血栓前状态。
