Lobo A J, Jones S C, Juby L D, Axon A T
Gastroenterology Unit, General Infirmary, Leeds.
J Clin Pathol. 1992 Jan;45(1):54-7. doi: 10.1136/jcp.45.1.54.
To assess the relation of plasma viscosity to disease activity in patients with inflammatory bowel disease.
Crohn's disease (n = 60) and ulcerative colitis (n = 71) were diagnosed on the basis of typical histological or radiological features. Active Crohn's disease was defined as a Crohn's disease activity index of 150 or over. Active ulcerative colitis was defined as a liquid stool passed three times a day or more with blood. Blood samples were assessed for haemoglobin concentration, total white cell count, platelets, plasma viscosity, erythrocyte sedimentation rate, serum albumin, and C-reactive protein.
Plasma viscosity was higher in those with active Crohn's disease compared with those with inactive Crohn's disease or active ulcerative colitis. Plasma viscosity correlated significantly with erythrocyte sedimentation rate, C-reactive protein, and platelet count in patients with Crohn's disease. In ulcerative colitis plasma viscosity correlated only with serum C-reactive protein. Plasma viscosity showed a low sensitivity for detecting active Crohn's disease, with 48% of those with active disease having a plasma viscosity within the laboratory reference range.
Plasma viscosity is related to disease activity in Crohn's disease, but is insufficiently sensitive for it to replace erythrocyte sedimentation rate as a measure of the acute phase response in Crohn's disease.
评估炎症性肠病患者血浆黏度与疾病活动度之间的关系。
根据典型的组织学或放射学特征诊断克罗恩病（n = 60）和溃疡性结肠炎（n = 71）。活动性克罗恩病定义为克罗恩病活动指数为150或更高。活动性溃疡性结肠炎定义为每天有三次或更多次带血的稀便。对血样进行血红蛋白浓度、白细胞总数、血小板、血浆黏度、红细胞沉降率、血清白蛋白和C反应蛋白的评估。
与非活动性克罗恩病或活动性溃疡性结肠炎患者相比，活动性克罗恩病患者的血浆黏度更高。在克罗恩病患者中，血浆黏度与红细胞沉降率、C反应蛋白和血小板计数显著相关。在溃疡性结肠炎中，血浆黏度仅与血清C反应蛋白相关。血浆黏度对检测活动性克罗恩病的敏感性较低，48%的活动性疾病患者的血浆黏度在实验室参考范围内。
血浆黏度与克罗恩病的疾病活动度相关，但敏感性不足以替代红细胞沉降率作为克罗恩病急性期反应的指标。
