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[一名甲状腺功能亢进母亲在孕早期服用甲巯咪唑后所生女孩出现双侧肾缺如(波特综合征)]

[Bilateral renal agenesis (Potter's syndrome) in a girl born to a hyperthyroid mother who received methimazole in early pregnancy].

作者信息

Rodríguez-García R

机构信息

Servicio de Pediatría, Hospital General de Zona No. 32, Instituto Mexicano del Seguro Social, Minatítlán, Veracruz, México.

出版信息

Ginecol Obstet Mex. 1999 Dec;67:587-9.

Abstract

Bilateral kidney agenesias (Potter syndrome) in a newborn of a hyperthyroid woman receiving methimazole during early pregnancy. This is a clinical case of a hyperthyroid woman that received methimazole during early pregnancy who gave birth to a girl with bilateral kidney agenesis. The initial clinical data was the presence of oligohydramnios detected by an ultrasound (US) at 19 gestational weeks. Another US at the term of the gestation showed anhydramnios, absence of renal silhouettes and bladder, which was corroborated when the girl was born. She died two days after she was born. Sufficient evidence exists that the methimazole administered during the early pregnancy can cause diverse congenital malformations including Potter's syndrome.

摘要

一名甲状腺功能亢进的女性在孕早期服用甲巯咪唑,其新生儿出现双侧肾缺如(波特综合征)。这是一例甲状腺功能亢进的女性在孕早期服用甲巯咪唑后产下一名患有双侧肾缺如女婴的临床病例。最初的临床数据是在妊娠19周时超声检查发现羊水过少。妊娠足月时的另一次超声检查显示羊水过少、肾轮廓及膀胱缺失,女婴出生后证实了这一情况。她出生两天后死亡。有充分证据表明,孕早期服用的甲巯咪唑可导致包括波特综合征在内的多种先天性畸形。

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