Ochiai K, Kikuchi K, Fukushima K, Kurita-Ochiai T
Department of Microbiology, Nihon University School of Dentistry, Chiba, Japan.
J Oral Sci. 1999 Sep;41(3):117-22. doi: 10.2334/josnusd.41.117.
The pathogenicity of strains of the Streptococcus sanguis group, isolated from infective endcarditis, was studied by measuring the development of subcutaneous abscesses in mice after infection with S. sanguis and Actinomyces viscosus either singly or as co-aggregated pairs. The pathogenicity of the co-aggregates was also examined in various viable combinations of the two bacterial species. More abscesses were formed by A. viscosus than the S. sanguis group including clinical isolates. Abscess formation by co-aggregates of combinations of each isolate and A. viscosus produced a higher percentage of abscess formation than those caused by infection with a pure suspension of A. viscosus or tested streptococci. Co-aggregated cells were more resistant to phagocytosis and killing by neutrophils in vivo. These results indicated that S. sanguis group streptococci isolated from infective endocarditis are able to co-aggregate and resist phagocytosis. The ability of co-aggregation of S. sanguis may serve as a survival mechanism in a host defense system and may be linked with virulence of this bacteria.
通过测量小鼠在单独感染血链球菌或粘性放线菌，或感染作为共聚集对的这两种细菌后皮下脓肿的发展情况，研究了从感染性心内膜炎中分离出的血链球菌群菌株的致病性。还在这两种细菌的各种活组合中检查了共聚集物的致病性。与包括临床分离株在内的血链球菌群相比，粘性放线菌形成的脓肿更多。每种分离株与粘性放线菌组合的共聚集物形成脓肿的百分比高于由粘性放线菌纯悬液或受试链球菌感染引起的脓肿形成百分比。共聚集细胞在体内对中性粒细胞的吞噬和杀伤更具抵抗力。这些结果表明，从感染性心内膜炎中分离出的血链球菌群链球菌能够共聚集并抵抗吞噬作用。血链球菌的共聚集能力可能作为宿主防御系统中的一种生存机制，并且可能与这种细菌的毒力有关。
