Ochiai K, Kurita-Ochiai T, Kamino Y, Ikeda T
Department of Microbiology, Nihon University, School of Dentistry at Matsudo, Chiba, Japan.
J Med Microbiol. 1993 Sep;39(3):183-90. doi: 10.1099/00222615-39-3-183.
The pathogenicity of oral bacteria was studied by measuring the development of subcutaneous abscesses in mice after infection with Actinomyces viscosus and Streptococcus mitis either singly or as co-aggregated pairs. Heat-treated cells were also tested. The pathogenicity of the co-aggregates was examined in various viable and heat-treated combinations of the two bacterial species. More abscesses were formed by A. viscosus than S. mitis at all the bacterial concentrations tested. Also, abscess formation by co-aggregates of the two strains produced a higher percentage of abscess formation than those caused by infection with pure suspensions of A. viscosus or S. mitis. Co-aggregated cells were more resistant to phagocytosis and killing by neutrophils in vitro and in vivo. Furthermore, A. viscosus in co-aggregates were resistant to killing after engulfment by neutrophils. These results suggest that oral bacteria that are able to co-aggregate may resist phagocytosis, and this ability may be linked with pathogenicity.
通过测量感染粘性放线菌和缓症链球菌单独或作为共聚集对的小鼠皮下脓肿的发展情况，研究了口腔细菌的致病性。还测试了热处理的细胞。在两种细菌的各种活的和热处理的组合中检查了共聚集物的致病性。在所有测试的细菌浓度下，粘性放线菌形成的脓肿比缓症链球菌多。此外，两菌株的共聚集物形成脓肿的百分比高于纯粘性放线菌或缓症链球菌悬浮液感染所引起的脓肿形成百分比。共聚集细胞在体外和体内对中性粒细胞的吞噬和杀伤更具抗性。此外，共聚集物中的粘性放线菌在被中性粒细胞吞噬后对杀伤具有抗性。这些结果表明，能够共聚集的口腔细菌可能抵抗吞噬作用，并且这种能力可能与致病性有关。
