[东莨菪碱对大鼠皮层电位空间组织的影响]

[The effect of scopolamine on the spatial organization of rat cortical potentials].

作者信息

Koshtoiants O Kh, Korol'kova T A, Kozhechkin S N, Kozhedub R G, Sviderskaia N E, Petukhova E G, Balashova A N

机构信息

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 Nov-Dec;49(6):1052-6.

PMID:10693286

Abstract

The influence of scopolamine (1 mg/kg, i.p.) on the spatial organization of the neocortical electrical activity was studied in rats. A decrease in the spectral power and coherence of brain potentials in the range of the dominant theta-rhythm peak (6.00-7.25 Hz) and their increase in the adjacent low-frequency band were observed. Both indices were decreased in the wide beta band (19.00-30.00 Hz). The described changes took place over the whole areas of the right hemisphere and parieto-temporal region of the left hemisphere. The obtained results are discussed with respect to the role of the cholinergic brain system in the higher nervous activity.

摘要

研究了东莨菪碱（1毫克/千克，腹腔注射）对大鼠新皮质电活动空间组织的影响。观察到在主要θ节律峰值范围（6.00 - 7.25赫兹）内脑电位的频谱功率和相干性降低，而在相邻低频带中则增加。在宽β波段（19.00 - 30.00赫兹），这两个指标均降低。上述变化发生在右半球和左半球顶颞区域的整个区域。结合胆碱能脑系统在高级神经活动中的作用对所得结果进行了讨论。