Vorobyov V V, Ahmetova E R
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142292, Russian Federation.
Brain Res. 1998 Jun 1;794(2):299-303. doi: 10.1016/s0006-8993(98)00256-x.
Averaged frequency spectra (0.5-30 Hz) of electroencephalogram (EEG) were studied in six freely moving rats with chronically implanted electrodes in symmetrical areas of somatosensory cortex. Hemispheric asymmetry in spectra of an ongoing EEG was expressed as a power decrease in 15.6-17.2 Hz band on the left hemisphere and as that in 25.2-27.8 Hz band on the right one. Physostigmine subcutaneous (s.c.) injection (0.25 mg/kg) provoked appearance of the significant left brain bias in 4.7-8.6 Hz range of EEG spectra and the right brain bias in 19.3-21.3 Hz band. These physostigmine effects were counteracted by scopolamine (1.5 mg/kg, s.c.) injected 30 min before. It is suggested that a muscarinic component may be involved in the interhemispheric cooperation associated with cortical theta activity in rats.
