13-去甲亮氨酸胃动素对健康受试者小肠转运时间的影响。
Effect of 13-Nle-motilin on small intestinal transit time in healthy subjects.
作者信息
Ruppin H, Sturm G, Westhoff D, Domschke S, Domschke W, Wünsch E, Demling L
出版信息
Scand J Gastroenterol Suppl. 1976;39:85-8.
PMID:1069367
Abstract
In 6 female subjects without gastrointestinal diseases, 13-norleucine motilin (13-Nle-M) synthetic and biological analogue of the duodenal polypeptide, motilin, caused acceleration of intestinal transit time. Intravenous infusion of 0.4 mug/kg-h of 13-Nle-M reduced mean transit time by 50 percent. No side effects occurred during infusion of the polypeptide. Radiographic appearance of small intestinal peristalsis and mucosal relief was not influenced by 13-Nle-M.
摘要
在6名无胃肠道疾病的女性受试者中，十二指肠多肽胃动素的13-去甲亮氨酸胃动素（13-Nle-M）合成及生物类似物可使肠道转运时间加快。以0.4微克/千克·小时的速率静脉输注13-Nle-M可使平均转运时间缩短50%。在输注该多肽过程中未出现副作用。小肠蠕动的影像学表现及黏膜缓解情况不受13-Nle-M影响。
Zotero 插件