急性腹泻中的肠道激素
Gut hormones in acute diarrhoea.
作者信息
Besterman H S, Christofides N D, Welsby P D, Adrian T E, Sarson D L, Bloom S R
出版信息
Gut. 1983 Jul;24(7):665-71. doi: 10.1136/gut.24.7.665.
Abstract
The gut hormone response to a breakfast meal was studied in 12 subjects hospitalised for an episode of acute diarrhoea (presumed infective) who were otherwise well and in 13 healthy control subjects. Fasting blood glucose concentrations were low but basal insulin concentrations were raised. Basal concentrations of pancreatic polypeptide and both basal and postprandial responses of motilin, enteroglucagon, and vasoactive intestinal polypeptide (VIP) were also significantly greater than controls. No abnormalities in plasma concentrations of gastrin, gastric inhibitory polypeptide (GIP) or pancreatic glucagon were found. The suggested physiological actions of the raised hormones may be relevant to the pathophysiology of diarrhoea.
摘要
对12名因急性腹泻发作（推测为感染性）而住院但其他方面健康的受试者以及13名健康对照受试者进行了研究，观察他们对早餐的肠道激素反应。空腹血糖浓度较低，但基础胰岛素浓度升高。胰腺多肽的基础浓度以及胃动素、肠高血糖素和血管活性肠多肽（VIP）的基础浓度和餐后反应也均显著高于对照组。未发现胃泌素、胃抑制性多肽（GIP）或胰高血糖素的血浆浓度有异常。所升高的激素的推测生理作用可能与腹泻的病理生理学有关。
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