Betteridge D J
Department of Medicine, Sir Jules Thorn Institute, The Middlesex Hospital, London, UK.
Metabolism. 2000 Feb;49(2 Suppl 1):3-8. doi: 10.1016/s0026-0495(00)80077-3.
Oxidative stress, defined as a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses, is discussed in relation to its possible role in the production of tissue damage in diabetes mellitus. Important free radicals are described and biological sources of origin discussed, together with the major antioxidant defense mechanisms. Examples of the possible consequences of free radical damage are provided with special emphasis on lipid peroxidation. Finally, the question of whether oxidative stress is increased in diabetes mellitus is discussed.
氧化应激被定义为活性氧（自由基）生成与抗氧化防御之间平衡的紊乱，本文将探讨其在糖尿病组织损伤产生中可能发挥的作用。文中描述了重要的自由基并讨论了其生物学来源，同时还介绍了主要的抗氧化防御机制。文中给出了自由基损伤可能导致的后果示例，并特别强调了脂质过氧化。最后，本文讨论了糖尿病中氧化应激是否增加的问题。
