Sergeev S I, Bergol'ts V M, Kovalev B N, Timofeevskaia E A
Vopr Onkol. 1976;22(8):17-21.
Studies on humoral immunity were performed in sarcoma patients before, during and after the treatment. Cytotoxic test was carried on with target cells of human mesenchymoma stable line. The activity of serum and its immunoglobulin fractions in 15 patients with soft tissue sarcoma and in 10 patients with congenital sarcoma was studied. It was found that 19S fraction of patient's blood serum contains cytotoxic antibodies. 7S fraction was permanently inactive. The whole serum was cytoloxic before the treatment in 8 of 12 patients with soft tissue sarcoma. Among 20 healthy donors only 3 were active. There was revealed a possibility of strong specific binding of 19S immunoglobulins (and more rarely of 7S immunoglobulins) with target-cells surface. It evidences the capacity of immunoglobulins to render not only cytotoxic action but also presumably, a blocking effect. Irradiation treatment in doses of 1800-9000 rad fail to diminish the cytotoxic activity of the whole serum and its 19S fraction.
对肉瘤患者在治疗前、治疗期间和治疗后进行了体液免疫研究。用人间充质瘤稳定系的靶细胞进行细胞毒性试验。研究了15例软组织肉瘤患者和10例先天性肉瘤患者血清及其免疫球蛋白组分的活性。发现患者血清的19S组分含有细胞毒性抗体。7S组分一直无活性。12例软组织肉瘤患者中有8例在治疗前全血清具有细胞毒性。在20名健康供体中只有3人有活性。发现19S免疫球蛋白（较少见的是7S免疫球蛋白）与靶细胞表面有很强的特异性结合可能性。这证明免疫球蛋白不仅具有细胞毒性作用，而且可能还具有阻断作用。1800 - 9000拉德剂量的照射治疗未能降低全血清及其19S组分的细胞毒性活性。
