Wild G E, Papalia P, Ropeleski M J, Faria J, Thomson A B
Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.
Can J Gastroenterol. 2000 Feb;14(2):99-110. doi: 10.1155/2000/608248.
Progress in the basic sciences of cell and molecular biology has provided an exciting dimension that has translated into clinically relevant information in every medical subspecialty. Importantly, the application of recombinant DNA technology has played a major role in unravelling the intricacies related to the molecular pathophysiology of disease. This series of review articles constitutes a framework for the integration of the database of new information into the core knowledge base of concepts related to the pathogenesis of gastrointestinal disorders and liver disease. The goal of this series of three articles is to review the basic principles of eukaryotic gene expression. The first article examines the role of DNA in directing the flow of genetic information in eukaryotic cells.
细胞与分子生物学基础科学的进展带来了令人兴奋的局面，已转化为各个医学亚专业领域中与临床相关的信息。重要的是，重组DNA技术的应用在揭示与疾病分子病理生理学相关的错综复杂问题方面发挥了主要作用。这一系列综述文章构成了一个框架，用于将新信息数据库整合到与胃肠道疾病和肝脏疾病发病机制相关的核心概念知识库中。这三篇文章系列的目标是回顾真核基因表达的基本原理。第一篇文章探讨了DNA在指导真核细胞中遗传信息流动方面的作用。
