Hustin J
Acta Cytol. 1976 Nov-Dec;20(6):556-8.
Twelve endometrial cancers have been observed before and during progestogen treatment. Eight were well-differentiated and displayed an objective response. It was essentially characterized by a volumetric reduction of the nucleus and the disappearance of tetraploid nuclei. The DNA content remained diploid or near-diploid. Reduction of nuclear non DNA proteins under hormonal treatment is suggested.
在孕激素治疗前及治疗期间观察到12例子宫内膜癌。其中8例为高分化，并显示出客观反应。其主要特征是细胞核体积减小和四倍体核消失。DNA含量保持二倍体或接近二倍体。提示激素治疗可使核内非DNA蛋白减少。
