一种解决人类肿瘤细胞群体异质性问题的方法。
An approach to the problem of heterogeneity of human tumour-cell populations.
作者信息
Sirachý J
出版信息
Br J Cancer. 1979 May;39(5):570-7. doi: 10.1038/bjc.1979.103.
Abstract
- Successive sampling of ovarian cancers during cytostatic treatment showed several cases of notable changes in their ploidy distribution and one change in model chromosome number, indicating selection of a resistant tumour-cell population. 2. Studies of cell suspensions from human tumour specimens incubated with [3H]-TdR after exposure in vitro to various cytostatic agents have shown variation in labelling between different parts of the same tumour, as well as between the primary tumour and its metastases or ascitic tumour-cell population, which may be accounted for by variation in sensitivity of the tumour-cell population. 3. Studies of nuclear morphology in 20 endometrial cancers before and after progesterone therapy demonstrate considerable variation in the proportion of cells undergoing secretory conversion within the same tumour, indicating primary heterogeneity of the tumour-cell population in response to progesterone.
摘要
- 在细胞抑制治疗期间对卵巢癌进行连续采样，结果显示有几例其倍性分布发生显著变化，还有一例模型染色体数发生变化，这表明出现了耐药肿瘤细胞群的选择。2. 对来自人类肿瘤标本的细胞悬液进行研究，这些细胞悬液在体外暴露于各种细胞抑制剂后再用[3H] - 胸腺嘧啶核苷（[3H]-TdR）孵育，结果显示同一肿瘤的不同部位之间以及原发性肿瘤与其转移灶或腹水肿瘤细胞群之间的标记存在差异，这可能是由肿瘤细胞群敏感性的差异所致。3. 对20例子宫内膜癌在孕激素治疗前后的核形态进行研究，结果表明同一肿瘤内发生分泌转化的细胞比例存在相当大的差异，这表明肿瘤细胞群对孕激素的反应存在原发性异质性。
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