Berger J, Dyck J L, Galan P, Aplogan A, Schneider D, Traissac P, Hercberg S
IRD (Institut de Recherche pour le Développement), Nutrition Unit, 911 Avenue Agropolis, BP 5045, 34032 Montpellier Cedex, France.
Eur J Clin Nutr. 2000 Jan;54(1):29-35. doi: 10.1038/sj.ejcn.1600888.
To assess the impact of a daily oral iron supplementation on hematological status, cell-mediated immunity and susceptibility to infections in children living in an environment where iron deficiency, malaria and other infections are frequent.
Randomized, double-blind iron supplementation including a placebo group.
A village in Togo, West Africa.
Of the 229 6-36-month-old children of both sexes recruited, 197 with hemoglobin concentration >/=80 g/l were included and 163 completed the study.
Children received daily a placebo (n=79) or a dose of 2-3 mg of elemental iron per kg of body weight (n=84) for 3 months. Hematological, nutritional and immune status were assessed at the beginning and at the end of the supplementation period, and 6 months later. Morbidity was recorded throughout the study.
Iron supplementation had a significant and positive effect on iron status of children and no impact on the incidence of infections, especially malaria. Its probable effect on immune status was masked by interference of infections and their treatment, which contributed to improve hematological and immune status in both groups.
According to the negative consequences of anemia and iron deficiency on global child development, control of iron deficiency by oral iron supplementation in young children has to be conducted, associated with prophylaxis and treatment of malaria and repeated deworming.
Program supported by IRD. European Journal of Clinical Nutrition (2000) 54, 29-35
评估每日口服铁补充剂对生活在缺铁、疟疾和其他感染频发环境中的儿童血液学状况、细胞介导免疫及感染易感性的影响。
随机、双盲铁补充剂研究，包括安慰剂组。
西非多哥的一个村庄。
招募的229名6至36个月大的儿童中，197名血红蛋白浓度≥80g/L的儿童被纳入研究，163名完成了研究。
儿童每日接受安慰剂（n = 79）或每公斤体重2 - 3毫克元素铁剂量（n = 84），为期3个月。在补充期开始和结束时以及6个月后评估血液学、营养和免疫状况。在整个研究过程中记录发病率。
铁补充剂对儿童铁状况有显著的积极影响，对感染发病率，尤其是疟疾发病率无影响。其对免疫状况的可能影响被感染及其治疗的干扰所掩盖，这有助于改善两组的血液学和免疫状况。
鉴于贫血和缺铁对全球儿童发育的负面影响，必须通过给幼儿口服铁补充剂来控制缺铁，并同时进行疟疾预防和治疗以及反复驱虫。
由法国国家科研中心支持的项目。《欧洲临床营养学杂志》（2000年）54卷，29 - 35页
