Berger J, Aguayo V M, Téllez W, Luján C, Traissac P, San Miguel J L
ORSTOM (French institute of scientific research for the development in cooperation), Nutrition Unit 44, Montpellier, France.
Eur J Clin Nutr. 1997 Jun;51(6):381-6. doi: 10.1038/sj.ejcn.1600418.
To compare the efficacy of a daily and a weekly iron supplementation on the hematological status of anemic children living at high altitude.
Double blind iron supplementation trial including a placebo control group.
A socioeconomically disadvantaged district of La Paz, Bolivia (altitude of 4000 m).
Anemic (hemoglobin concentration < or = 144 g/L), 3.3-8.3 y old children of both sexes.
Children received a placebo (n = 57) or a dose of 3-4 mg of elemental iron per kg body weight (FeSO4 tablets) 1 d per week (n = 58) or 5 d per week (n = 58) for 16 weeks.
Hemoglobin and zinc erythrocyte protoporphyrin concentrations improved significantly in supplemented groups but not in the placebo group. Changes in hemoglobin during the study were not significantly different between supplemented groups (weekly group: 15.2 +/- 6.9 g/L and daily group: 18.6 +/- 11.1 g/L) but were different from the placebo group (0.5 +/- 7.1 g/L, P < 0.001). At the end of the supplementation period, the hemoglobin distribution was Gaussian, and similar in both supplemented groups. Adjusting for the initial hemoglobin concentration, final hemoglobin and its changes were similar in both supplemented groups.
Weekly iron supplementation is as efficacious as daily iron supplementation in improving iron status and correcting moderate iron deficiency anemia in Bolivian school children living at high altitude.
Program supported in part by ORSTROM, the French Ministry of Foreign Affairs and the National Secretary's Office of Health, Bolivia.
比较每日补铁和每周补铁对生活在高海拔地区贫血儿童血液学状况的疗效。
双盲补铁试验，包括一个安慰剂对照组。
玻利维亚拉巴斯一个社会经济条件较差的地区（海拔4000米）。
贫血（血红蛋白浓度≤144克/升）、3.3 - 8.3岁的男女儿童。
儿童接受安慰剂（n = 57）或每公斤体重3 - 4毫克元素铁剂量（硫酸亚铁片），每周1天（n = 58）或每周5天（n = 58），持续16周。
补铁组血红蛋白和锌原卟啉红细胞浓度显著改善，而安慰剂组未改善。研究期间，补铁组之间血红蛋白变化无显著差异（每周补铁组：15.2±6.9克/升，每日补铁组：18.6±11.1克/升），但与安慰剂组不同（0.5±7.1克/升，P < 0.001）。补铁期结束时，血红蛋白分布呈高斯分布，两组补铁组相似。调整初始血红蛋白浓度后，两组补铁组最终血红蛋白及其变化相似。
对于生活在高海拔地区的玻利维亚学童，每周补铁在改善铁状态和纠正中度缺铁性贫血方面与每日补铁同样有效。
该项目部分由法国国家科研中心（ORSTROM）、法国外交部和玻利维亚国家卫生部资助。
