Hübscher U, Nasheuer H P, Syväoja J E
Institute of Veterinary Biochemistry, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Trends Biochem Sci. 2000 Mar;25(3):143-7. doi: 10.1016/s0968-0004(99)01523-6.
In eukaryotic cells, DNA polymerases are required to maintain the integrity of the genome during processes, such as DNA replication, various DNA repair events, translesion DNA synthesis, DNA recombination, and also in regulatory events, such as cell cycle control and DNA damage checkpoint function. In the last two years, the number of known DNA polymerases has increased to at least nine (called alpha, beta, gamma, delta, epsilon, zeta, eta, t and iota), and yeast Saccharomyces cerevisiae contains REV1 deoxycytidyl transferase.
在真核细胞中，DNA聚合酶在诸如DNA复制、各种DNA修复事件、跨损伤DNA合成、DNA重组等过程中，以及在细胞周期控制和DNA损伤检查点功能等调节事件中，对于维持基因组的完整性都是必需的。在过去两年中，已知的DNA聚合酶数量已增加到至少九种（称为α、β、γ、δ、ε、ζ、η、θ和ι），并且酿酒酵母含有REV1脱氧胞苷转移酶。
