刘易斯血型和癌胚抗原相关抗原；共同表达的细胞间黏附分子，在肿瘤的生物学进展和扩散中发挥作用。
Lewis blood group and CEA related antigens; coexpressed cell-cell adhesion molecules with roles in the biological progression and dissemination of tumours.
作者信息
Sanders D S, Kerr M A
机构信息
Department of Histopathology, University of Birmingham, Medical School, Edgbaston, Birmingham, UK.
出版信息
Mol Pathol. 1999 Aug;52(4):174-8. doi: 10.1136/mp.52.4.174.
Abstract
The Lewis blood group and carcinoembryonic antigen (CEA) related antigens have adhesive functions in human tissues, with roles in embryonic sorting and migration of cells (organogenesis), differentiation and protection of normal mucosal tissues, migration of neutrophils, bacterial binding, and tumour differentiation and dissemination. In the key areas of mucosal protection, neutrophil binding, and tumour metastasis, they are often coexpressed on the outer cell membrane, with Lewis blood group antigens forming the terminal carbohydrate chains on a CEA related glycoprotein backbone. The central role of these antigens in the mechanism of neutrophil binding to endothelium in inflammation highlights a fascinating paradigm for tumour cell dissemination and metastasis, and expression is linked to disease prognosis. This review outlines the structure, function, and comparative roles of these antigens in human tissues.
摘要
刘易斯血型和癌胚抗原（CEA）相关抗原在人体组织中具有黏附功能，在细胞的胚胎分选和迁移（器官发生）、正常黏膜组织的分化和保护、中性粒细胞的迁移、细菌结合以及肿瘤的分化和扩散中发挥作用。在黏膜保护、中性粒细胞结合和肿瘤转移的关键区域，它们通常共表达于细胞膜外，刘易斯血型抗原在CEA相关糖蛋白主链上形成末端碳水化合物链。这些抗原在炎症中中性粒细胞与内皮细胞结合机制中的核心作用凸显了肿瘤细胞播散和转移的一个引人入胜的范例，且其表达与疾病预后相关。本综述概述了这些抗原在人体组织中的结构、功能及比较作用。
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