Wong D T, Bowen S M, Elovic A, Gallagher G T, Weller P F
Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Oral Oncol. 1999 Sep;35(5):496-501. doi: 10.1016/s1368-8375(99)00023-8.
Tissue eosinophilia in squamous cell carcinoma has long been recognized; however, the role of eosinophils in tumor development remains unclear. Studies have reported both favorable and unfavorable prognoses for patients with tumors exhibiting tumor-associated tissue eosinophilia (TATE). This study seeks to elucidate the potential role of the eosinophil in squamous cell carcinoma development and provide an experimental model for future studies. The carcinogen-induced hamster oral cancer model was found to fulfill these objectives. Eosinophils progressively infiltrate into this carcinogen-induced oral cancer model. We now demonstrate that TATE is completely abolished by the use of an anti-interleukin-5 monoclonal antibody (mAb) preparation, TRFK-5. Clinical observations revealed that TRFK-5-treated hamsters exhibited smaller tumor burden and delayed onset of tumor development. The results suggest that anti-interleukin-5 antibody treatment may delay and/or inhibit tumor development, and that eosinophils may have a tumor-promoting role.
鳞状细胞癌中的组织嗜酸性粒细胞增多现象早已为人所知；然而，嗜酸性粒细胞在肿瘤发展中的作用仍不清楚。研究报告称，肿瘤伴有肿瘤相关组织嗜酸性粒细胞增多（TATE）的患者预后既有良好的，也有不良的。本研究旨在阐明嗜酸性粒细胞在鳞状细胞癌发展中的潜在作用，并为未来研究提供一个实验模型。发现致癌物诱导的仓鼠口腔癌模型符合这些目标。嗜酸性粒细胞逐渐浸润到这个致癌物诱导的口腔癌模型中。我们现在证明，使用抗白细胞介素-5单克隆抗体（mAb）制剂TRFK-5可完全消除TATE。临床观察显示，经TRFK-5治疗的仓鼠肿瘤负荷较小，肿瘤发展的起始时间延迟。结果表明，抗白细胞介素-5抗体治疗可能会延迟和/或抑制肿瘤发展，并且嗜酸性粒细胞可能具有促进肿瘤的作用。
