Jereb B, Wollner N, Exelby P
Cancer. 1979 Mar;43(3):1037-42. doi: 10.1002/1097-0142(197903)43:3<1037::aid-cncr2820430338>3.0.co;2-n.
Thirteen girls with malignant ovarian tumors treated at Memorial Hospital from August 1971 through October 1975 with extensive surgery, multi-drug chemotherapy (T-2 protocol) and postoperative radiation were reviewed. The plan of radiation was to deliver 3,000 rads to the whole abdomen and boost the para-aortic and pelvic area with 1,500 rads in five to six weeks. In only two patients was the radiation conducted as planned. In others the treatment was either interrupted or discontinued due to complications. Four of the thirteen patients are dead. The cause of death in two of these patients was distant metastases; the two other patients died without evidence of tumor due to treatment complications. Three of the nine patients who are alive without evidence of disease have late complications. Following radical surgery, lower doses of radiation given concomitantly with T-2 protocol chemotherapy seem to be sufficient for controlling the disease.
对1971年8月至1975年10月期间在纪念医院接受治疗的13例患有恶性卵巢肿瘤的女孩进行了回顾。她们接受了广泛的手术、多药化疗（T-2方案）和术后放疗。放疗计划是在五到六周内对全腹给予3000拉德的辐射剂量，并对腹主动脉旁和盆腔区域追加1500拉德的辐射剂量。只有两名患者按计划进行了放疗。在其他患者中，由于并发症，治疗被中断或停止。13名患者中有4名死亡。其中两名患者的死因是远处转移；另外两名患者因治疗并发症死亡，尸检未发现肿瘤。9名存活且无疾病证据的患者中有3名有晚期并发症。根治性手术后，较低剂量的放疗与T-2方案化疗同时进行似乎足以控制疾病。
