Chiba K, Kurosawa M, Kondo T, Suzuki S, Musashi M, Asaka M, Imamura M, Hattori Y, Oba Y
Third Department of Internal Medicine, Hokkaido University, School of Medicine.
Rinsho Ketsueki. 2000 Jan;41(1):61-4.
A 55-year-old man was admitted to our hospital because of leukocytosis and microcytic anemia with hypochromia, target cells, and increased levels of hemoglobin A2 and hemoglobin F. The results of a gene analysis yielded a diagnosis of chronic myelogenous leukemia and beta-thalassemia minor. A gradual increase in hemoglobin was observed during hydroxyurea therapy, which was performed over a 12-week period. This increment appeared to be due to suppressed production of myeloid cells. It was been reported that hydroxyurea increases total hemoglobin due to increased hemoglobin F synthesis in patients with beta-thalassemia. However, hydroxyurea had no clear influence on hemoglobin concentration in this case.
一名55岁男性因白细胞增多、小细胞低色素性贫血、靶形细胞以及血红蛋白A2和血红蛋白F水平升高入住我院。基因分析结果诊断为慢性粒细胞白血病合并β-地中海贫血轻型。在为期12周的羟基脲治疗期间，观察到血红蛋白逐渐升高。这种升高似乎是由于髓系细胞生成受到抑制。据报道，在β-地中海贫血患者中，羟基脲可因血红蛋白F合成增加而使总血红蛋白升高。然而，在该病例中，羟基脲对血红蛋白浓度并无明显影响。
